TRAF7, KLF4, AKT1, and SMO alterations are mutually exclusive with NF2 mutation, are typically found in meningiomas localized to the skull base, and are associated with a more favorable prognosis.4,43 In contrast, NF2 mutations are enriched in meningiomas of the convexities/falx and in higher-grade tumors. The gene discussed is SMO; the disease is meningioma.