Our results demonstrated that genipin crosslinked hydrogels show off better results of disc healing in the repaired zone than the Fibrinogen with suture group in rats, as well as support mechanical strain up-regulated AF tissue markers Mohawk, SOX-9 and ECM markers COL2 and aggrecan after application in MSCs, exhibit trends that are consistent with those reported with regard to fibrous tissues (Baker et al., 2011; Elsaadany et al., 2017). The gene discussed is ACAN; the disease is atrial fibrillation.