In general, our results showed that DKK3 expression in cancer (Figure 5A) is reduced (62.8%) compared to normal adjacent epithelial (100%), which is consistent with the DKK3 pattern of expression demonstrated in European patients (7), apart from the higher expression of DKK3 in cancer stroma (91.8%) compared to normal adjacent stroma (50%), which is unique to the Middle Eastern patients and requires further elucidation with a higher sample size (Figure 5A). The gene discussed is DKK3; the disease is cancer.