Initially and to evaluate the rate of DKK3 mutation in a large cohort of PCa patients, we investigated the rate of DKK3 genetic alteration in prostate adenocarcinoma samples (Broad/Cornell, NAT Genet, 2012) through the publicly available database cBioPortal (http://www.cBioPortal.org/public-portal) (Figures 1A–C). Here, DKK3 is linked to prostate adenocarcinoma.