Similar to genomic profiling, transcriptome analyses also supported SPA as a potential subgroup for immunotherapy, with significantly increased expression of signatures related to response to immunotherapy (27, 31, 32) (CD8 T effector, immune checkpoint, IFNγ-6, chemokine, and APM signature and GEP score) and an inflamed tumor immune microenvironment characterized by higher infiltration of TILs (CD8+T cells, M1 macrophages, Th1 and Th2 cells). This evidence concerns the gene CD8A and neoplasm.