Based on the expression pattern of tumor-infiltrating T cells (TIL) and B7-H1 (PD-L1), the tumor immune microenvironment was classified as four types: T1 (B7-H1−, TIL−), T2 (B7-H1+, TIL+), T3 (B7-H1−, TIL+), and T4 (B7-H1+, TIL−) (24, 25), among of which, the Type II was most likely to respond to ICIs. Here, CD274 is linked to neoplasm.