Mature DCs take up tumor antigens, which finally presented as major histocompatibility complex class I (MHC-I) antigenic tumor peptides complex on DCs surface, migrate to the draining lymph nodes, where initial tumor-specific T helper type 1 (Th1) CD4+ T cells and CD8+ cytotoxic T lymphocytes (CTLs) are induced by antigen cross-presentation (9). The gene discussed is CD4; the disease is neoplasm.