IFNs are classified into three types: type I (IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω), type II (IFN-γ), and type III (IFN-λ), which have multiple roles in anti-tumor cell proliferation, promotion of apoptosis, anti-angiogenesis, increasing antigen processing and presentation of APCs. This evidence concerns the gene IFNA1 and neoplasm.