SERPINA1 and systemic lupus erythematosus: Intriguingly, SLE patients with mild activity and moderate to severe activity had higher urinary exosomes derived tRF3-Ile AAT-1 (P = 0.035 and P < 0.001) and tiRNA5-Lys-CTT-1 (P = 0.021 and P < 0.001) levels compared with patients with no activity, whereas there was no difference of tRF3-Ile-AAT-1 and tiRNA5-Lys-CTT-1 between SLE patients with mild activity and moderate to severe activity (both P > 0.05) (Figures 6C, F).