Elevated expression of tRF3-Ile-AAT-1, tiRNA5-Lys-CTT-1, tiRNA5-Arg-CCT-4, and tRF5-Arg-TCG-3 were measured in the urinary exosomes of LN compared with SLE without LN patients (Figures 4B–J), implying urinary exosomes derived tsRNAs may serve as promising biomarkers for the diagnosis of LN. This evidence concerns the gene TBPL2 and systemic lupus erythematosus.