RIGI and ovarian cancer: In addition, when ovarian cancer cells were exposed to LPS, known to recognize and activate TLR, or Poly(I:C), known to activate the cytosolic RNA helicases as RIG-I and MDA-5 (21), induction of IFN-stimulated genes (ISG) was only observed with poly(I:C) treatment, further supporting the more prominent role of RNA sensors in IFN-mediated response in ovarian cancer cells (Supplementary Figure 2).