SAMHD1 (sterile alpha motif and histidine/aspartic acid domain-containing protein 1) is a cellular deoxynucleotide (dNTP) triphosphohydrolase that has been recently linked to tumour initiation and development, although with controversial findings, either being recognized as a tumour suppressor in haematological cancers (9, 10) or tumour promoting in several solid tumours, including ovarian cancer (11). This evidence concerns the gene SAMHD1 and ovarian cancer.