Considering the key role of SAMHD1 in the induction of IFN-mediated immune activation derived from its role in DNA damage repair (16, 19), together with reported deficiencies in nucleic acid sensing and subsequent loss of innate immune activation in ovarian cancer (20), we focused our attention on innate immune response and cytosolic pattern recognition receptors (PRRs). The gene discussed is IFNA1; the disease is ovarian cancer.