SAMHD1 and breast cancer: Although transcriptomic data may vary between cell types, our results in breast cancer cells are also in accordance with previous transcriptomic data from monocytic cells where SAMHD1-KO clones showed dysregulation of several immune signalling pathways, such as RIG-I like receptors, IFN and cytokine signalling pathways (18) and thus, prompted the evaluation of similar pathways in ovarian cancer models.