SAMHD1 and ovarian carcinoma: Interestingly, exploring the ovarian cancer proteome using TCGA transcriptomics data obtained from Human Protein Atlas database (www.proteinatlas.org) (22), we observed that high expression of several innate immune activation hallmark genes was associated to improved ovarian cancer survival, supporting the idea that upregulation of innate immune response is linked to better prognosis in ovarian cancer, a mechanism that is regulated by SAMHD1, as demonstrated in vitro (Supplementary Figure 4).