SAMHD1 and cancer: Moreover, it has also been shown that chronic interferon response in SAMHD1-KO mice was driven by the MDA5 pathway in close concordance with our data in ovarian cancer cells (25) and further supporting the idea that SAMHD1 depletion is able to enhance innate immune activation and inflammation in cancer cells, a process that might have an important impact on ovarian cancer clinical outcome.