SAMHD1 and ovarian cancer: In our study, we show that depletion of SAMHD1 in ovarian cancer cells leads to upregulation of RNA helicases and also several IFN-stimulated genes, as cytokines and chemokines, suggesting an activation of innate immune signalling pathways that could trigger an inflammatory response in the tumour site (Figure 2C) and may ultimately affect patient prognosis.