SHANK3 and Sepsis: Furthermore, homozygous CKO mice exhibited more rapid (within 1 hour, p=0.0038) and more lasting (>48 hours, p < 0.0001) hypothermia, as compared to Shank3f/f mice (Figure 2C), suggesting that Shank3 deficiency in sensory neurons accelerates the induction of hypothermia and delays the resolution of hypothermia after sepsis.