As soluble ICAM-1 (sICAM-1), and the C5 complement pathway have been shown to be associated with lung fibrosis (35–38), we measured lung tissue concentrations of sICAM-1 and complement proteins, Complement Factor Bb (CF-Bb) and C5b9 by ELISA across two independent experiments (shown as Expt#4 and Expt#5 in Figure 8). Here, ICAM1 is linked to pulmonary fibrosis.