In our secondary analysis, using three SNPs as IVs (rs767455, rs4149570, and rs4149577), results from the IVW and the PCA method did not show an association between genetically indexed inhibition of TNF-TNFR1 and risk of periodontitis (OR: 0.57, 95% CI: 0.12;2.57, and OR: 0.57, 95% CI: 0.13;2.63, respectively). Here, TNF is linked to periodontitis.