The intervention of RA-FLSs with resveratrol significantly increases the expression of Nrf2 and HO-1, reduces the production of ROS and MDA and activation of nuclear factor kappa-B (NF-κB) p65, inhibits the proliferation and migration of RA-FLSs, and promotes its apoptosis (114, 115). This evidence concerns the gene HMOX1 and rheumatoid arthritis.