Recently, ZBP1 has been found to be involved in the occurrence and development of various tumors, including breast cancer (71–74), melanoma (75–77), colorectal cancer (76, 77), non-small cell lung cancer (76), multiple myeloma (78), ovarian cancer (79), urothelial carcinoma (80), fibrosarcoma (71), and kidney renal clear cell carcinoma (81). This evidence concerns the gene ZBP1 and melanoma.