SERPINE1 and Thrombocytopenia: There are several different components of the coagulation, anti-coagulation, and fibrinolytic pathways that have been identified to be altered during heatstroke both in human and animal models, such as increased plasminogen activator inhibitor 1 (PAI-1), increased thrombin/anti-thrombin (TAT) complex, thrombocytopenia, decreased fibrinogen (Fib) levels, increased D-dimer levels, delayed prothrombin time (PT), and delayed activated partial thromboplastin time (APTT) (21, 133, 134).