Adar1fl/flLysMcre mice were found to be resistant to the development of colorectal cancer and melanoma, Adar1fl/flLysMcre mice were found to be resistant to the development of colorectal cancer and melanoma due to the pro-tumorigenic effect of ADAR1 by inhibiting PANoptosis through binding to the Zα2 domain of ZBP1 (85). The gene discussed is ADAR; the disease is colorectal cancer.