Compared with WT BMDMs, the activation of CASP1/GSDMD/GSDME, CASP8/3/7, and RIPK3/MLKL in Mefv–/– and Zbp1–/– BMDMs decreased after infection with HSV1 or F. novicida, and completely inactive in Aim2–/– and Mefv–/–Zbp1–/– BMDMs (8). Here, AIM2 is linked to infection.