While upregulated genes were mainly enriched in regulation of trans-synaptic signaling, modulation of trans-synaptic transmission, cellular response to nitrogen compound, cell junction organization, cell-cell signaling, inorganic ion transmembrane transport, regulation of membrane potential and anterograde trans-synaptic signaling which were associated with the neural glial cell development in tumor initiation stage consistent with that TSPAN7 were highly expressed in LGG (27). Here, TSPAN7 is linked to neoplasm.