Liu and colleagues demonstrated that CXCR3+ B cells infiltrate predominantly in hepatocellular carcinoma invading edge and are associated with tumor recurrence, furthermore, CXCR3+ B cells induce TAMs repolarization into M2 macrophages through an IgG-dependent manner and promote hepatocellular carcinoma progression (129). The gene discussed is CXCR3; the disease is hepatocellular carcinoma.