HSPA1A and disease arising from reactivation of latent virus: For example, latent infection of herpes simplex virus-2 (HSV-2) increased the HSPs in human neuroblastoma cells, HSP70 mRNA levels increased in mouse L cells after HSV-1 and HSV-2 infection, and the expression level of HSP70 and HSP90 were increased in human B lymphocytes infected with EB virus (13–15).