HSPA14 and infection: At the same time, we only explored the effect of HSPA14 on HIV-1 replication by simulating the infection state with HIV pseudovirus, which may be different from the state of the infection state with real HIV-1 virus.Overall, this study showed that HSPA14 can inhibit HIV-1 replication, which provides a research basis for further exploration of its usage as a target for inhibition of HIV replication.