These proinflammatory macrophages, together with infiltrating macrophages dictated by LPS, interferon-γ, and granulocyte-macrophage colony stimulatory factor (GM-CSF) signaling, are commonly classified as M1 macrophages as opposed to M2 macrophages that usually arise in Th2 responses in allergy, granuloma formation, and wound healing (10). This evidence concerns the gene CSF2 and Allergy.