Importantly, correlation analyses indicated a positive association between the severity of RA disease (DAS28‐CRP, DAS28‐ESR, CRP, ESR, and joint swollen) and the expression of TGM2, Myc, WTAP, IL1A, IL1B, CCNA2, and CCNB1 as well as the negative correlation between therapy response (delta DAS28‐CRP, delta DAS28‐ESR, delta CRP, and delta ESR) and TGM2, Myc, WTAP, IL1A, IL1B, CCNA2, and CCNB1 expression (Figure 8F) based on the PEAC RNA‐seq database. Here, ESR1 is linked to rheumatoid arthritis.