Using primary RA‐FLS from RA patients and an immortalized RA‐FLS cell line, animal models, as well as available public databases, we measured the impact of OS on anti‐RA effect of MTX as well as proliferation and metastasis of RA‐FLS to determine its anti‐RA activity and detected the modulation of m6A‐modified TGM2 expression induced by OS. This evidence concerns the gene TGM2 and rheumatoid arthritis.