Age, sex, BMI, hypertension, diabetes, history of cardiovascular diseases, cancer, or arthritis, high C-reactive protein, smoking and drinking habits, physical activity, cognitive status, impaired instrumental activities of daily living, body pain, education, living alone, marital status, serum albumin concentration, total energy intake, intakes per 2,000 kcal of energy intake as protein and folate, tea consumption (for coffee analysis), coffee consumption (for tea analysis), perceived social support, visiting friends. The gene discussed is CRP; the disease is arthritic joint disease.