Furthermore, three randomized phase III trials comparing combination targeted therapy vs. BRAF inhibitor monotherapy were conducted among patients with unresectable BRAF V600 mutated melanoma: COMBI-v (DAB+TRAM vs. vemurafenib) (16), coBRIM (VEM+COBI vs. vemurafenib) (17), and COLUMBUS (ENCO+BINI vs. encorafenib and vemurafenib) (18). The gene discussed is BRAF; the disease is melanoma.