TRPM8 and cancer: observed that the overexpression of TRPM8 channels increased basal autophagy levels, while TRPM8 knockdown reduced it, in different types of mammalian cancer cells, including cervical cancer (HeLa), breast cancer (MDA-MB-231 and MCF7), embryonic kidney (HEK293) and colorectal carcinoma (HCT116) (9).