TRPM1 elevates [Ca2+]-cytosolic levels and activates Ca2+/calmodulin-dependent protein kinase IIδ (CaMKIIδ), promoting AKT activation after CaMKIIδ/AKT interaction, cell mobility, colony formation, and tumor growth in an in vivo (xenograft) melanoma cell model (215). The gene discussed is AKT1; the disease is neoplasm.