TRPM8 affects glioblastoma (GBM) cell migration rate by stimulation with specific agonists, such as menthol and icilin, which mediated a substantial increase in [Ca2+]i (345, 346), while contributes to proliferation, survival, and local tumor invasion in the case of U251 glioblastoma cells (347). The gene discussed is TRPM8; the disease is glioblastoma.