TRPM7 and hepatocellular carcinoma: This fact, together with the increase in senescence-associated ß-galactosidase activity, ERK phosphorylation, GTP loading of Ras, and TNFSF10 and p16INK4a expression, indicated that TRPM7 lack of function contributes to oncogene-induced senescence of hepatocarcinoma (HCC) cells.