SIRT2 and neoplasm: Compared with adjacent normal tissues, a significant decrease in SIRT2 expression was observed in tumor tissue of BRCA, KIRP, LUAD, LUSC, and UCEC, which are consistent with the TIMER2.0 database, while SIRT2 expression was significantly lower in OV, TGCT and UCEC tumor tissues and higher in LGG compared to adjacent normal tissues via GEPIA2 (Figure 1C).