SIRT2 and brain cancer: Supplementary Table S1 describes the detailed relationship between the expression levels of SIRT2 and the prognostic potential of various cancers. In particular, the expression level of SIRT2 affected OS in brain cancer (OS HR = 0.31, 95% CI = 0.15 to 0.64, Cox P = 0.001496), lung cancer significantly (OS HR = 0.58, 95% CI = 0.38 to 0.87, Cox P = 0. 0.009042), moreover SIRT2 also affected relapse free survival of lung cancer (OS HR = 0.66, 95% CI = 0.46 to 0.94, Cox P = 0.020039) (Supplementary Table S1).