PF can significantly increase the expression of hippocampal complex CA1 and phosphorylated CREB (p-CREB) in post-stroke depression (Hu et al., 2019) and significantly increases the rate of sucrose consumption and 5-bromo-2-deoxyuridine-positive cells in the dentate gyrus of rats induced by CUMS. Here, CREB1 is linked to depressive symptom measurement.