Antidepressants increase hippocampal neurogenesis (Hill et al., 2015) and studies have shown that serum- and glucocorticoid-inducible kinase 1 (SGK1) was related to depression, which is a mediator of the influence of cortisol on neurogenesis and glucocorticoid receptor (GR) function. This evidence concerns the gene NR3C1 and major depressive disorder.