Furthermore, ROC analysis was performed to validate the sensitivity and specificity of the prognostic signature.SLC2A2 encodes glucose transporter protein 2 (GLUT2), which is associated with glycolysis and gluconeogenesis in the liver via the HNF4a-GLUT2 pathway that can affect the uptake and utilization of glucose by HCC cells and is involved in the systemic metabolism of cancer cachexia [36, 37]. This evidence concerns the gene SLC2A2 and cancer.