RHOA and triple-negative breast carcinoma: A mechanism underlying the antitumor effects of miR-31 has been clarified in triple negative breast cancer (TNBC) tissues and cell lines [25], in which miR-31 directly targeted protein kinase C (PKC) in the NF-ҝB signaling pathway, while in prostate cancer cell lines [24], miR-31 indirectly controlled the PI3K/AKT signaling pathway via targeting integrins and inhibited several metastasis-promoting genes such as RhoA and RDX [14] to repress tumor invasion and migration.