Also, Tzivion et al. observed miR-375 could function as an antitumor factor for GC via targeting YWHAZ, an oncogene associated with cell survival signaling, cell cycle, and apoptosis [44]; while our data demonstrated the exosomal miR-375 significantly upregulated in GC patients compared to negative controls, we also found that a high expression level of ex-miR-375 was associated with poor OS in GC patients. This evidence concerns the gene YWHAZ and gastric cancer.