ESR1 and breast cancer: Figures 5(c) and 5(d) are the ultrasound images of a 63-year-old female breast cancer patient before and after NAC, ER negative (28 points), hyperechoic halo narrowing after NAC (38 points), Alder grade 1 (66 points) points), the diameter change reached PR (28 points), and the morphological changes were not obvious (0 points).