↑Serum LDH, CK, CK-MB levels, ANP, & BNP, ↓Expressions of ANP, ANF, BNP, a-SKA, & b-MHC genes, ↑Heart volume, ↑Heart weight, ↑Ratio of heart weight to shank bone length, ↓Edema & cavitation, ↓Expression of Bax, ↑Expression of Bcl-2, ↓ Caspase-3, & -9 protein expression, ↑Mitochondrial drill arrays, & swollen mitochondria, ↓ ROS level, ↓ Ca2+ overload, ↑ ATP content, ↑ MMR capacity, ↑ OXPHOS complexes, ↑ UCP3, ↑ ATP5D, ↓ mtDNA copy number, ↑ Tumor weight. The gene discussed is NPPB; the disease is neoplasm.