Therefore,it has become a highly significant therapeutic target for the drugdiscovery against PCa.6,7 AR has 919 amino acid residuesand consists of three major domains: N-terminal domain (NTD) (residues1–555), DNA binding domain (DBD) (residues 555–623),and the C-terminal ligand binding domain (LBD) (residues 665–919),which is connected to the DBD by a flexible hinge region (residues623–665). This evidence concerns the gene AR and posterior cortical atrophy.