The vascular endothelialgrowth factor (VEGF) is one of the most potent angiogenic determinantsthat can control angiogenesis and be involved in the development ofa tumor among those growth factors.10 Byinteracting with VEGF receptor types 1–3, the VEGF family controlsangiogenesis.11 The VEGFR-2 binding siteis hydrophobic, hence VEGFR-2 inhibitors showed a wide variety ofchemical configurations. Here, KDR is linked to neoplasm.