Furthermore, our TSPO PET results have translational value as TSPO tracers are also used clinically and imaging studies observed increased proinflammatory states and TSPO upregulation in the hippocampus, amygdala, prefrontal cortex, and the anterior cingulate cortex in people suffering from major depressive disorder (Gritti et al., 2021; Kim and Won, 2017). Here, TSPO is linked to major depressive disorder.