ANGPT2 and cutaneous mastocytosis: Nevertheless, measurement of Ang-1 and Ang-2 can help improve confidence in the diagnosis of CM when used in conjunction with other biomarkers such as CXCL10, sFlt-1, PCT, sTREM-1 and sICAM-1; in 2011, these biomarkers were used in combination with Ang-2 to predict mortality in Ugandan children with SM, and together showed 95.7% sensitivity and 88% specificity in differentiating fatal and non-fatal cases (Erdman et al., 2011).