identified MBP, SAMSN1, PSMF1, SLC39A8, EIF3B, SMPDL3A, FABP5, SPSB3, and SHARPIN genes, which were associated with CM, and suggested that these genes may be good potential targets or immune modulators for novel therapeutic interventions of CM (Li et al., 2021). The gene discussed is SMPDL3A; the disease is cutaneous mastocytosis.