CXCL10 is produced by many cells, including endothelial cells, hepatocytes, and astrocytes (Park et al., 2006; Hassanshahi et al., 2007; Vazirinejad et al., 2014), and is implicated both in recruitment of cells to the original site of infection, but also across the BBB and into the brain, inducing CM progression. Here, CXCL10 is linked to infection.