In addition to upregulated genes, pediatric TB is also characterized by downregulated genes, with pathways primarily engaged in stimulation of T or B cells (CD40L, CD7, ICOS, FCER2, PTPRCAP, and ADAM23), dendritic cell development (FLT3LG), alternative promoters of inflammation (CD248 and EDAR), and inhibition of neutrophil degranulation by ADORA3. The gene discussed is CD40LG; the disease is tuberculosis.