In a recent review article by Guo et al. (40) describing the signaling pathways involved in melanoma, including the mitogen-activated protein kinase (MAPK) pathway, protein kinase B (AKT) pathway, cell cycle regulation pathway, pigmentation-related pathway, and p53 pathway, epigenetic factors were also mentioned as one of the crucial factors in melanoma carcinogenesis. This evidence concerns the gene TP53 and melanoma.