This complex consists of 15 subunits encoded by 28 genes, including SMARCB1 (also known as SNF5, BAF47, and INI1), SMARCC1/SMARCC2 (also known as BAF155 and BAF170), and one of the two mutually exclusive ATPase subunits, SMARCA4 (also known as BRG1) and SMARCA2 (also known as BRM), which are commonly mutated in 20% of human cancers (1). The gene discussed is SMARCC1; the disease is cancer.