BET inhibitors (RVX2135 or iBET762) in combination with ATRIs [Ataxia-telangiectasia and Rad3-related (ATR) is a kinase belonging to the PI3 kinase-like family; VE821 or AZ20], showed apoptosis effect on melanoma cells as well as the PDX model of melanoma (45). This evidence concerns the gene ATR and melanoma.