Atrophy and reduced functional activation were widely reported in the prefrontal cortex and hippocampus of the diabetes.7,8 Both of these regions are specific areas that are insulin-sensitive in the human brain34; hence, behaviours associated with those regions could be altered in conditions where insulin and glucose levels are dysregulated.35 The VLPFC was implicated in inhibitory control of emotional distractions. This evidence concerns the gene INS and diabetes mellitus.