SLC6A3 and synucleinopathy: The hypermetabolism in the pallidum associated with the reduction of dopamine transporter activity in the putamen may reflect a disruption of the inhibitory input from the striatum to the pallidum, which occurs early in synucleinopathies.89,90Figure 4 displays a schematic representation of some of the excitatory and inhibitory connections within the nigrostriatal pathway.