Individuals who use insulin glulisine (such as glargine) can have symptoms similar to IAS, usually manifesting as postprandial hypoglycemia, obvious neurological symptoms and changes in their state of consciousness, accompanied by high titers of insulin autoantibodies and serum hyperinsulinemia, so the concept of nonclassical IAS was proposed to distinguish it from the previous classic IAS. This evidence concerns the gene INS and hyperinsulinism.