TP53 and colon adenocarcinoma: Moreover, we compared the IC50 between samples with high risk and low risk, and the result showed that the high-risk group had lower IC50 compared to the low-risk group in three drugs including IGFR-3801, Staurosporine, and Sabutoclax (Figure 6B), which indicated that IGFR-3801, Staurosporine, and Sabutoclax were potential agents for high-risk COAD with TP53 mutations.