SGPP1 is a catalyze of Sphingosine-1-phosphate (S1P), the latter is a bioactive sphingolipid metabolite that regulates diverse biologic processes (31, 32), and SIP is linked to signal transducer and activator of transcription 3 (STAT3) activation and the development of colitis-associated colorectal cancer (32). This evidence concerns the gene STAT3 and colitis.