In this study, we established a prognostic signature particular for COAD patients with TP53 mutations by 16-genes including GALK1, TGIF2, TAPBPL, SPINK1, ZNF500, LAMC1, MICB, RPL8, EEF1D, MAPKBP1, ZNF250, RFX3, ETV1, SERINC3, DIP2C, and AKT3. Here, RFX3 is linked to colon adenocarcinoma.