Zhou et al. (2022b) and Fu et al. (2022) also observed similar results to the current study, suggesting that CRGs were closely related to immune checkpoints. Bian et al., (Liao et al., 2022) also reported that in renal cancer, a prognostic risk score with CRGs expression signature exhibited good performance in predicting OS and PFS of patients and was significantly correlated with the level of immune infiltration and PD-L1 expression, which was in consistent with our results. The gene discussed is CD274; the disease is renal carcinoma.