And it has been shown that hyperglycemia can disrupt the stability of HIF-1α through a von Hippel-Lindau tumor suppressor protein-dependent mechanism, resulting in HIF-1α destabilization and inhibition of its downstream genes, especially VEGF expression, which is a central pathogenic mechanism for the delayed healing of diabetic wounds (Botusan et al., 2008). Here, HIF1A is linked to Hyperglycemia.