In addition, CircRNA NFIB has been found to be lowly expressed in heart tissue of MI mouse and TGF-β-treated cardiac fibroblasts, and its expression inhibits the cardiac fibroblasts proliferation by a mechanism related to sponging miR-433 to upregulate the AZIN1 and JNK1 and inhibit the cardiac fibroblasts proliferation (Zhu et al., 2019). This evidence concerns the gene TGFB1 and myocardial infarction.