The lncRNA Cfast is highly expressed in heart tissue of MI mouse, and Cfast competitively interacts with COTL1 to prevent COTL1 from binding to TRAP1, thereby enhancing the formation of the TRAP1/Smad2/Smad4 complex and thus activating the TGF-β signaling pathway (Zhang et al., 2020c). Here, COTL1 is linked to myocardial infarction.