Gu et al. (2022) reported that Long Sheng Zhi Capsule (LSZ) inhibited the AngII-induced cardiac hypertrophy and fibrosis and rescued the expression of miR-150-5p treated with AngII; While miR 150-5p overexpression ameliorated the AngII-induced cardiac hypertrophy and fibrosis by attenuating the cardiac hypertrophy and fibrosis through MMP14 (Table 7; Figure 3). This evidence concerns the gene MMP14 and cardiac hypertrophy.