In addition, miR-1 was reported to exhibit an increased expression in the hypoxia-induced RV of PAH model rats, inhibiting the expressions of collagen I, collagen III, a-SMA, and CTGF, the further study revealed that expressions of p-phosphatidylinositol 3-kinase (PI3K) and p-AKT are upregulated in hypoxia-induced cardiac fibroblasts and are reversed by the transfected miR-1 antagomiR (Liu et al., 2021a). The gene discussed is AKT1; the disease is pulmonary arterial hypertension.