TMBIM4 and COVID-19: FLV is a potent S1R agonist that modulates inflammation by reducing mast cell downregulation, cytokine production, platelet aggregation, interference with endolysosomal viral transport, and delayed clinical deterioration, all of which have been shown to have a strong antiviral effect, control coagulopathy, or alleviate the cytokine storm, all of which have been known cornerstones of extreme COVID-19.