Moreover, common mutations associated with cataracts of various morphologies include genes encoding crystallins (CRYA, CRYB, and CRYG), lens specific connexins (Cx43, Cx46, and Cx50), major intrinsic protein (MIP) or aquaporin, heat shock transcription factor 4 (HSF4), etc. but PAX6 is neglected [15-22]. The gene discussed is HSF4; the disease is cataract.