Similarly, an increase in serum LH levels was related to an 18.5% lower risk of MetS only in postmenopausal women (OR: 0.815; 95% CI: 0.690, 0.962; and P= 0.016), but not in premenopausal women (P= 0.469) and perimenopausal women (P= 0.426). The gene discussed is PLOD1; the disease is metabolic syndrome.