Interferon IFN-y can down-regulate the expression of transporter proteins SLC7A11 and SLC3A2 in tumor cells, inhibit the input of cysteine required for glutathione synthesis, cause intracellular glutathione depletion, and thus indirectly lead to glutathione peroxidase-4 (GPX4) inactivation and ultimately induce iron death in tumor cells (44). The gene discussed is GPX4; the disease is neoplasm.