In some cell types, such as prostate cancer cells, Zn has been seen to induce mitochondrial apoptogenesis associated with an increase in the cellular level of Bax (67), whereas either cellular or mitochondrial Bcl-2 was stalled, such that the Bax/Bcl-2 ratio is increased, which is a pro-apoptotic condition. This evidence concerns the gene BCL2 and prostate carcinoma.