The proportion of AIPvar(+) acromegalic patients was similar (4.8% vs. 4.1%) as reported by Cazabat et al., and higher in the case of ACTH-producing (9.1% vs. 6.8% in Cazabat’s study) or non-secreting/gonadotropin-secreting adenomas (4.7% vs. 0.9%, respectively) (22). Here, POMC is linked to adenoma.