Symptoms: phenotypical features of acromegalyImaging: pituitary tumor of 10 x 14 mm in MRIDiagnosis: acromegalyTherapeutic approach first line: long-acting somatostatin analogue with subsequent transsphenoidal resection of the tumorHistopathological examination: pituitary somatotropic adenoma (immunohistochemical staining: GH+, PRL+/-, Ki-67 <1%)Follow-up: IGF-1 concentration was within the normal range, although there was no GH suppression in the oral glucose tolerance test. MRI showed no tumor recurrence. This evidence concerns the gene IGF1 and neoplasm.