Symptoms: proximal myopathy of the lower limbs, right eye ptosis, double vision, and signs of heart failure.Imaging: pituitary tumor of 25x18x22 mm in CTDiagnosis: Cushing’s disease.Therapeutic approach first line: transsphenoidal tumor resectionHistopathological examination: corticotropic pituitary adenoma with Crooke cells (immunohistochemical staining: ACTH+, Ki67 index – approx. 3%)Therapeutic approach second line: stereotactic radiotherapy, ketoconazole for hypercortisolism (due to progressive tumor on MRI in the next hospitalization)Follow-up: the patient was lost for follow-up. This evidence concerns the gene MKI67 and pituitary tumor.