The possible reasons why HCV causes PTDM are: that HCV virus directly replicates in pancreatic islet β cells, causing dysfunction of pancreatic β cells and autoimmune destruction, resulting in insufficient insulin synthesis and secretion; HCV directly damages liver cells, resulting in insulin utilization disorders in liver cells, resulting in insulin resistance; and HCV can also affect the synthesis of insulin-related proteins by mediating the insulin signaling pathway, and ultimately affecting insulin secretion (69). The gene discussed is INS; the disease is Insulin resistance.