ESR1 and neoplasm: reported that ASC1 can be ufmylated at the sites of Lys69, Lys324, Lys 325, Lys334, and Lys367, and ufmylated ASC1 enhances the ability of ERα recruited transcription co-factors, increasing the target genes expression, thereby affecting the intracellular homeostasis and ultimately tumor formation (14).