FOXO1 and obesity due to melanocortin 4 receptor deficiency: Hyperlipidemia caused as a result of inhibition of PI3K/AKT signaling by ExomiR-450b-3p as a result of phosphorylation of FOXO1 transcription factor (57, 58) not only leads to adiposity-induced insulin resistance by impairing with GLUT-4 trafficking (56), but also the hypertensive disorder of PE as a result of obesity(Figure 3).