Moreover, the authors mentioned that several different factors, such as NLRP3, PI3K/AKT/mTOR, or NFκB, are involved in the pathogenesis of AP and/or CP, though a detailed correlation between them and OS was not evaluated (Xue, et al. 2019; Kong et al. 2021; Tarasiuk et al. 2021). This evidence concerns the gene NLRP3 and alkaline phosphatase measurement.